Ex Vivo Metrics™, a preclinical tool in new drug development
2008
Ex Vivo Metrics: A New Tool for Drug Development
Commentary
Evidence: moderate
Author Information
Author(s): Curtis C Gerald, Bilyard Kevin, Stephenson Hugo
Primary Institution: Bowman Research, Inc.
Hypothesis
Can Ex Vivo Metrics improve drug development productivity and safety?
Conclusion
Ex Vivo Metrics could enhance drug candidate selection and safety by providing relevant data before human trials.
Supporting Evidence
- Ex Vivo Metrics uses ethically donated human organs to provide relevant data for drug testing.
- This technology allows for better drug candidate selection before costly clinical trials.
- Ex Vivo Metrics can help explain why some drugs fail in clinical trials after showing promise in preclinical studies.
Takeaway
Ex Vivo Metrics is a new way to test drugs using real human organs, which helps scientists find the best medicines faster and safer.
Methodology
The technology uses intact human organs to test drug candidates in a controlled environment.
Limitations
The perfused organs are disconnected from the host's immune and nervous systems, which may affect certain toxicity outcomes.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website