Fibrinogen Albumin Ratio and Diabetic Peripheral Neuropathy in Type 2 Diabetes
Author Information
Author(s): Muacevic Alexander, Adler John R, Rathod Mitali B, Teja Reddy Anuka, Nagaraju Bhavya, Chanthu Jr, Arumugaperumal Dheepika, Ashwini Maria Sneha
Primary Institution: NAMO Medical College and Research Centre, Silvassa, India
Hypothesis
The study investigates the association between the fibrinogen-to-albumin ratio (FAR) and nerve conduction abnormalities in type 2 diabetic patients with diabetic peripheral neuropathy (DPN).
Conclusion
FAR serves as a simple and effective biochemical marker for the assessment of DPN severity.
Supporting Evidence
- The prevalence of DPN was 55% among the study population.
- Fibrinogen levels were significantly higher in DPN patients compared to non-DPN patients.
- Albumin levels were lower in DPN patients compared to non-DPN patients.
- FAR was significantly higher in DPN patients compared to non-DPN patients.
- Conduction velocities were significantly reduced in DPN patients across all nerves tested.
Takeaway
This study found that higher levels of a specific blood marker (FAR) are linked to worse nerve function in people with diabetes.
Methodology
This was a cross-sectional study conducted on 200 T2DM patients, with nerve conduction studies performed to evaluate motor and sensory nerve functions.
Potential Biases
The study did not consider other potential confounders, such as detailed lipid profiles or genetic predispositions.
Limitations
The study was limited by being single-center and having a relatively small sample size.
Participant Demographics
Patients aged 30 to 70 years with a confirmed diagnosis of T2DM for at least 5 years.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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