Gastric Changes After Long-Term Use of Vonoprazan: A Case Report
Author Information
Author(s): Suda Hiroko, Eto Sachi, Sakurai Koichi
Primary Institution: Hattori Clinic, Kumamoto, Japan
Hypothesis
What are the effects of long-term Vonoprazan use on gastric mucosa?
Conclusion
Long-term use of Vonoprazan can lead to significant gastric mucosal changes and severe rebound acid hypersecretion after discontinuation.
Supporting Evidence
- Vonoprazan use for 6 years led to significant gastric epithelial changes.
- The patient developed acute duodenal mucosal lesions after stopping Vonoprazan.
- Histological analysis showed parietal cell and G-cell hyperplasia.
- Rebound acid hypersecretion occurred despite high-dose H2 blocker therapy.
Takeaway
A 76-year-old man had serious stomach problems after taking a medicine called Vonoprazan for a long time, showing that stopping it can cause big issues.
Methodology
Case report detailing the clinical course and endoscopic findings of a patient using Vonoprazan for 6 years.
Limitations
Findings are based on a single case report, limiting generalizability.
Participant Demographics
76-year-old male with a history of hypertension and previous proton pump inhibitor use.
Digital Object Identifier (DOI)
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