Cognitive training plus a comprehensive psychosocial programme (OPUS) versus the comprehensive psychosocial programme alone for patients with first-episode schizophrenia (the NEUROCOM trial): A study protocol for a centrally randomised, observer-blinded multi-centre clinical trial
2011

Cognitive Training for Schizophrenia Patients

Sample size: 120 publication Evidence: moderate

Author Information

Author(s): Lone Vesterager, Torben Ø. Christensen, Birthe B. Olsen, Gertrud Krarup, Hysse B. Forchhammer, Marianne Melau, Christian Gluud, Merete Nordentoft

Primary Institution: Psychiatric Centre Copenhagen, Copenhagen University Hospital

Hypothesis

Does adding cognitive training to a comprehensive psychosocial program improve cognitive and everyday functional capacity in patients with first-episode schizophrenia compared to the psychosocial program alone?

Conclusion

The study aims to determine if cognitive training enhances the functional capacity and cognitive abilities of patients with schizophrenia more than the psychosocial program alone.

Supporting Evidence

  • Up to 85% of patients with schizophrenia show cognitive dysfunction.
  • Cognitive dysfunction is stable over time and independent of clinical state.
  • Previous studies have shown mixed results on the effectiveness of cognitive training.

Takeaway

This study is trying to see if teaching people with schizophrenia how to think better can help them do better in everyday life.

Methodology

The study is a randomized parallel-group clinical trial comparing cognitive training integrated with a psychosocial program to the psychosocial program alone over 16 weeks.

Potential Biases

The comprehensive psychosocial program may influence cognition positively, making it hard to determine the specific effects of cognitive training.

Limitations

The intensity of the cognitive training may reduce participation in the psychosocial program, and there is no control for the amount of clinician contact.

Participant Demographics

Outpatients aged 18-35 with first-episode psychosis or schizotypal disorder.

Digital Object Identifier (DOI)

10.1186/1745-6215-12-35

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