Evolutionary History of PRP8 Inteins in Fungi
Author Information
Author(s): Butler Margaret I, Gray Jeremy, Goodwin Timothy JD, Poulter Russell TM
Primary Institution: Department of Biochemistry, University of Otago
Hypothesis
The study investigates the distribution and evolutionary history of PRP8 inteins in various fungal species.
Conclusion
PRP8 inteins are widespread in euascomycetes, and their homing endonucleases appear to be active, suggesting vertical transmission rather than horizontal transfer.
Supporting Evidence
- 22 PRP8 inteins were detected in species from three different orders of euascomycetes.
- Some PRP8 inteins contain intact homing endonuclease domains, indicating potential mobility.
- The study suggests that the intein is of ancient origin and has been vertically transmitted.
Takeaway
This study looks at tiny pieces of proteins called inteins found in fungi, showing they are common and have been passed down through generations.
Methodology
The study involved screening fungal genomes for PRP8 inteins and conducting phylogenetic analyses.
Limitations
The study's findings are based on a limited number of species and may not represent all fungi.
Digital Object Identifier (DOI)
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