Annotation of mammalian primary microRNAs
2008

Annotation of Mammalian Primary MicroRNAs

publication Evidence: moderate

Author Information

Author(s): Harpreet K Saini, Anton J Enright, Sam Griffiths-Jones

Primary Institution: Wellcome Trust Sanger Institute

Hypothesis

What are the structures and boundaries of primary microRNAs expressed from intergenic regions in mammals?

Conclusion

The study successfully identifies and annotates the boundaries of a significant proportion of primary microRNAs in human, mouse, and rat genomes.

Supporting Evidence

  • The study annotates 59 pri-miRNA structures, including 82 pre-miRNAs.
  • 36 pri-miRNAs are conserved across human, mouse, and rat.
  • 54% of predicted pri-miRNAs are associated with regulatory sequences.

Takeaway

This study helps us understand how certain tiny RNA molecules, which control gene activity, are structured in different animals.

Methodology

The study used transcription features to predict the boundaries of primary microRNAs in human, mouse, and rat genomes.

Limitations

The study primarily focuses on intergenic miRNAs and may not cover all types of miRNAs.

Digital Object Identifier (DOI)

10.1186/1471-2164-9-564

Want to read the original?

Access the complete publication on the publisher's website

View Original Publication