Effects of Circadian Misalignment on Behavior in MAPT Humanized Mouse Model
2024
Effects of Circadian Misalignment on Behavior in a Mouse Model of Alzheimer's Disease
publication
Author Information
Author(s): Udenta Mesomachi, Gonzalez Andrea, Lin Qing, Dieterk Kristi, Koronowski Kevin, Palavicini Juan
Primary Institution: Howard University
Hypothesis
Circadian misalignment affects tau pathology in a MAPT humanized mouse model.
Conclusion
Circadian misalignment may influence tau pathology, which is important for understanding Alzheimer's Disease.
Supporting Evidence
- Circadian rhythm regulates sleep-wake cycles and is linked to neurodegenerative diseases.
- Tauopathies are a key feature of Alzheimer's Disease.
- The MAPT mouse model mimics human tau pathology.
Takeaway
This study looks at how not sleeping at the right times can affect brain health in mice that have a condition similar to Alzheimer's.
Methodology
A MAPT mouse model was used in conjunction with a chronic jet lag simulation.
Digital Object Identifier (DOI)
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