Shi-Liu-Wei-Liu-Qi-Yin and Its Effects on Bladder Cancer Cells
Author Information
Author(s): Ting-Tsz Ou, Wang Chau-Jong, Hung Guang-Uei, Wu Cheng-Hsun, Lee Huei-Jane
Primary Institution: Chung Shan Medical University
Hypothesis
The study aims to clarify the possible mechanisms of Shi-Liu-Wei-Liu-Qi-Yin (SLWLQY) in treating bladder cancer.
Conclusion
SLWLQY reduces tumor growth and induces cell-cycle arrest and apoptosis in human bladder carcinoma cells through the Fas and mitochondrial pathways.
Supporting Evidence
- SLWLQY treatment resulted in G2/M phase arrest in TSGH-8301 cells.
- Apoptotic cell death was confirmed by increased levels of caspases.
- SLWLQY significantly reduced tumor size in a mouse model.
- Fas and FasL protein expressions were up-regulated after SLWLQY treatment.
Takeaway
This study found that a traditional herbal medicine can help stop cancer cells from growing and make them die.
Methodology
The study used MTT assays for cytotoxicity, cell-cycle analysis, and western blot analysis on TSGH-8301 cells and a mouse model.
Participant Demographics
The study involved human bladder carcinoma TSGH-8301 cells and BALB/c nude mice.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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