Modulatory Effects of Mdivi-1 on OxLDL-Induced Metabolic Alterations, Inflammatory Responses, and Foam Cell Formation in Human Monocytes
2024
Effects of Mdivi-1 on Inflammation and Foam Cell Formation
publication
Author Information
Author(s): Mosalmanzadeh Negin, Maurmann Rafael Moura, Davis Kierstin, Schmitt Brenda Landvoigt, Makowski Liza, Pence Brandt D.
Primary Institution: Cold Spring Harbor Laboratory
Hypothesis
How do Mdivi-1 and S1QEL affect OxLDL-induced responses in human monocytes?
Conclusion
Mdivi-1 and S1QEL reduce harmful metabolic and inflammatory responses in monocytes caused by OxLDL.
Supporting Evidence
- OxLDL treatment increased glycolytic activity and pro-inflammatory cytokine expression.
- Mdivi-1 and S1QEL reduced glycolytic reprogramming and inflammatory cytokine levels.
- Both drugs limited foam cell formation and mitochondrial ROS production.
Takeaway
This study shows that two drugs can help stop bad changes in immune cells that happen when they are exposed to a harmful substance in the blood.
Methodology
Healthy monocytes were treated with OxLDL, with or without Mdivi-1 or S1QEL, and assessed for various metabolic and inflammatory responses.
Participant Demographics
Healthy monocytes isolated from participants.
Digital Object Identifier (DOI)
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