Naproxen and Pseudoporphyria in Children with Arthritis
Author Information
Author(s): Schäd Susanne G, Kraus Andrea, Haubitz Imme, Trcka Jiri, Hamm Henning, Girschick Hermann J
Primary Institution: University of Würzburg
Hypothesis
Is early onset pauciarticular arthritis a risk factor for naproxen-induced pseudoporphyria in juvenile idiopathic arthritis?
Conclusion
The study found that early onset pauciarticular arthritis is a significant risk factor for developing naproxen-induced pseudoporphyria in children.
Supporting Evidence
- The prevalence of naproxen-induced pseudoporphyria was found to be 11.4%.
- Children with early-onset pauciarticular JIA were significantly more likely to develop pseudoporphyria.
- 82% of children with pseudoporphyria developed lesions within 2 years of starting naproxen.
Takeaway
Some kids taking a medicine called naproxen for arthritis can get a skin problem called pseudoporphyria, especially if they started having arthritis when they were very young.
Methodology
The study included a retrospective review of 395 children and a prospective study of 196 children with juvenile idiopathic arthritis treated with naproxen.
Potential Biases
Potential bias from the pediatric rheumatologist's prior experience with the EOPA JIA subgroup.
Limitations
The study was not based on blinded generation of data, which may introduce bias.
Participant Demographics
196 children (128 girls and 68 boys) with juvenile idiopathic arthritis.
Statistical Information
P-Value
p<0.00001
Statistical Significance
p<0.00001
Digital Object Identifier (DOI)
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