The prokineticin receptor agonist Bv8 decreases IL-10 and IL-4 production in mice splenocytes by activating prokineticin receptor-1
2008
Bv8 Reduces Certain Cytokines in Mice
Sample size: 8
publication
Evidence: moderate
Author Information
Author(s): Franchi Silvia, Giannini Elisa, Lattuada Donatella, Lattanzi Roberta, Tian Hui, Melchiorri Pietro, Negri Lucia, Panerai Alberto E, Sacerdote Paola
Primary Institution: Department of Pharmacology, University of Milan
Hypothesis
Does the prokineticin receptor agonist Bv8 modulate T cell cytokine production in mice?
Conclusion
Bv8 is a novel modulator of lymphoid functions, reducing IL-4 and IL-10 production in mice.
Supporting Evidence
- Bv8 significantly increased IL-1β and decreased IL-4 and IL-10 in splenocytes.
- In vivo administration of Bv8 reduced IL-10 and IL-4 production in KLH-immunised mice.
- The effects of Bv8 were lost in mice lacking the PROKR 1 gene.
Takeaway
Bv8 is a substance that helps the immune system by lowering certain signals that can cause inflammation.
Methodology
Mice were treated with Bv8 and their splenocytes were analyzed for cytokine production after stimulation.
Participant Demographics
Balb/CJ mice, weighing 20–25 g.
Statistical Information
P-Value
<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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