Protective Effects of Pithecellobium dulce Against Liver Damage
Author Information
Author(s): Manna Prasenjit, Bhattacharyya Sudip, Das Joydeep, Ghosh Jyotirmoy, Sil Parames C.
Primary Institution: Bose Institute
Hypothesis
The aqueous extract of Pithecellobium dulce (AEPD) protects against carbon tetrachloride (CCl4)-induced hepatic injury.
Conclusion
AEPD effectively protects the liver from CCl4-induced oxidative damage and necrotic cell death.
Supporting Evidence
- AEPD reduced the levels of serum marker enzymes ALT and ALP in CCl4-treated mice.
- Histological assessments showed reduced necrosis in liver tissue after AEPD treatment.
- AEPD decreased intracellular reactive oxygen species (ROS) levels in liver cells.
- Treatment with AEPD improved the liver weight to body weight ratio in CCl4-intoxicated mice.
- AEPD showed significant antioxidant activity in cell-free systems.
Takeaway
This study shows that a fruit extract from a plant called Pithecellobium dulce can help protect the liver from damage caused by a harmful chemical.
Methodology
The study used a murine model to assess the protective effects of AEPD against CCl4-induced liver damage through various biochemical and histological analyses.
Potential Biases
Potential bias in the selection of animal models and the interpretation of results.
Limitations
The study was conducted on mice, and results may not directly translate to humans.
Participant Demographics
Swiss albino mice, male, body weight 20±2g.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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