Quality of Life in Adolescents with Sickle Cell Disease
Author Information
Author(s): Lamia P Barakat, Chavis A Patterson, Lauren C Daniel, Carlton Dampier
Primary Institution: Drexel University
Hypothesis
Internalizing symptoms and parenting stress mediate the relationship between pain and health-related quality of life in adolescents with sickle cell disease.
Conclusion
The study found that pain frequency negatively impacts health-related quality of life, and that internalizing symptoms and parenting stress are important mediators in this relationship.
Supporting Evidence
- Pain frequency was significantly correlated with lower health-related quality of life.
- Internalizing symptoms and parenting stress were identified as mediators in the relationship between pain and quality of life.
- Caregiver and teen reports showed differences in perceived health-related quality of life.
Takeaway
Kids with sickle cell disease who feel more pain also feel worse overall, and stress from their parents can make this worse.
Methodology
The study involved 42 adolescents with sickle cell disease and their caregivers completing measures of pain, psychological adjustment, and health-related quality of life.
Potential Biases
Self-reported measures may introduce bias, particularly in the assessment of pain and quality of life.
Limitations
The sample size was small and drawn from a single center, which may limit generalizability.
Participant Demographics
Participants were primarily African-American adolescents aged 12-18, with a majority having SCD-SS.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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