Menstrual and Reproductive Factors Related to Ovarian Cancer Risk
Author Information
Author(s): Titus-Ernstoff L, Perez K, Cramer D W, Harlow B L, Baron J A, Greenberg E R
Primary Institution: Dartmouth-Hitchcock Medical Center and Brigham and Women's Hospital
Hypothesis
How do menstrual and reproductive factors influence the risk of ovarian cancer?
Conclusion
The study found that certain reproductive factors, like having children and breastfeeding, are associated with a reduced risk of ovarian cancer.
Supporting Evidence
- Ovarian cancer risk was reduced among parous women compared to nulliparous women.
- Higher parity and increased age at first or last birth were associated with reduced risk.
- Breastfeeding was linked to lower risk of ovarian cancer.
Takeaway
Having kids and breastfeeding can help lower the chances of getting ovarian cancer.
Methodology
A large, population-based, case–control study was conducted with 563 ovarian cancer cases and 523 matched controls, using multivariate logistic regression.
Participant Demographics
Women from Massachusetts and New Hampshire.
Statistical Information
P-Value
P=0.0006
Confidence Interval
95% CI = 0.3−0.6
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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