Alternative splicing and expression of human and mouse NFAT genes
2008
Alternative Splicing and Expression of Human and Mouse NFAT Genes
publication
10 minutes
Evidence: high
Author Information
Author(s): Hanna Vihma, Priit Pruunsild, Tõnis Timmusk
Primary Institution: Tallinn University of Technology
Hypothesis
The study investigates the structures and alternative splicing of NFAT genes in humans and mice.
Conclusion
The study reveals that NFAT genes undergo complex alternative splicing, leading to diverse protein isoforms that may have distinct functions in various tissues.
Supporting Evidence
- NFAT genes are expressed in almost all tissues but with distinct levels and patterns.
- Alternative splicing leads to multiple isoforms of NFAT proteins, which may have different functions.
- Specific NFAT mRNAs were found in various brain regions of both humans and mice.
Takeaway
This study looks at how certain genes can be mixed up in different ways to create different proteins, which helps our bodies work properly.
Methodology
The study used bioinformatics and RT-PCR to analyze the structures and expression patterns of NFAT genes in human and mouse tissues.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website