Bone Density in Men with COPD
Author Information
Author(s): Duckers James M, Evans Bronwen AJ, Fraser William D, Stone Michael D, Bolton Charlotte E, Shale Dennis J
Primary Institution: Wales Heart Research Institute, Cardiff University
Hypothesis
Osteoporosis would be present in men with COPD of mild to moderate severity airways obstruction and that this would be related to disease factors such as the persisting chronic systemic inflammatory state.
Conclusion
Men with COPD had a greater prevalence of osteoporosis and osteopenia than age matched male controls, with a marked difference in BMD at the hip.
Supporting Evidence
- The majority of patients had GOLD II airflow obstruction.
- 17 patients and 5 controls were osteopenic.
- Bone biomarkers were inversely related to hip BMD in patients.
Takeaway
This study found that men with COPD often have weaker bones compared to other men their age, especially in the hip area.
Methodology
BMD, FEV1, circulating bone biomarkers, and biochemistry were measured in 30 male COPD patients and 15 age-matched controls.
Potential Biases
Potential confounding factors due to the selection of controls and the exclusion criteria.
Limitations
The study had a modest sample size and the controls and patients were not matched for smoking history.
Participant Demographics
30 male ex-smokers with COPD and 15 age-matched male controls.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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