Dietary Amino Acid Reduction Affects Metabolism in Mice
Author Information
Author(s): Al-Ishaq Raghad Khalid, Ferrara Carmen R., Stephan Nisha, Krumsiek Jan, Suhre Karsten, Montrose David C.
Primary Institution: Weill Cornell Medicine-Qatar
Hypothesis
How does reducing dietary amino acids affect the metabolome and microbiome in mice?
Conclusion
Reducing dietary amino acids significantly alters metabolic profiles across organ systems in mice.
Supporting Evidence
- Distinct metabolic profile changes were observed in liver, serum, and feces.
- Reducing non-essential amino acids had a more profound effect than reducing total protein.
- Microbial profiling showed significant differences in the abundance of select species across groups.
Takeaway
When mice eat less protein, their bodies change how they process food and their gut bacteria also change a little.
Methodology
Mice were fed different diets with varying levels of protein and amino acids, and their liver, serum, and feces were analyzed for metabolite and microbial changes.
Limitations
The study used a limited number of mice and increased dietary fat, which may have influenced the results.
Participant Demographics
Male 8-week old A/J mice
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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