Duloxetine vs Placebo for Stress Urinary Incontinence in Women
Author Information
Author(s): Lin Alex Tong-Long, Sun Mou-Jong, Tai Hui-Lung, Chuang Yao Chi, Huang Shih-Tsung, Wang Nick, Zhao Yan Daniel, Beyrer Julie, Wulster-Radcliffe Meghan, Levine Louise, Chang Curtis, Viktrup Lars
Primary Institution: Taipei Veterans General Hospital, Taipei, Taiwan
Hypothesis
Is duloxetine more effective than placebo in treating stress urinary incontinence in Taiwanese women?
Conclusion
Duloxetine is safe and effective for treating stress urinary incontinence in Taiwanese women.
Supporting Evidence
- Duloxetine-treated women had a 69.98% reduction in incontinence episodes compared to 42.56% in the placebo group.
- 80% of duloxetine-treated women experienced treatment-emergent adverse events.
- 26.7% of duloxetine-treated women discontinued due to adverse events compared to 6.6% in the placebo group.
Takeaway
This study shows that a medicine called duloxetine helps women in Taiwan who leak urine when they laugh or cough.
Methodology
Women with stress urinary incontinence were randomly assigned to receive either duloxetine or placebo for 8 weeks.
Potential Biases
Potential bias due to the involvement of employees from Eli Lilly in the study.
Limitations
The study did not include a placebo lead-in phase, which may have affected the number of reported adverse events.
Participant Demographics
Women aged 30-79 years with stress urinary incontinence.
Statistical Information
P-Value
<0.001
Confidence Interval
(-81.25, -53.57)
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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