TNF-Alpha Levels in Teeth with Apical Periodontitis
Author Information
Author(s): Pezelj-Ribarić Sonja, Magašić Karolina, Prpić Jelena, Miletić Ivana, Karlović Zoran
Primary Institution: Department of Oral Medicine, Medical Faculty, University of Rijeka; Department of Endodontology and Restorative Dentistry, University of Zagreb
Hypothesis
The study aims to determine tumor necrosis factor-alpha (TNF-α) levels in periapical exudates and evaluate their relationship with radiological findings.
Conclusion
TNF-α levels significantly increase in teeth with periapical pathosis as the size of the lesions increases.
Supporting Evidence
- TNF-α was present in all periapical exudate samples.
- Significant differences in TNF-α concentrations were found between control and groups with larger radiolucent areas.
- The study categorized TNF-α levels according to radiological diagnosis using the nonparametric Kruskal-Wallis test.
Takeaway
This study found that a substance called TNF-α is higher in teeth with bigger problems, showing that it can help understand dental issues.
Methodology
Periapical exudates were collected from root canals of 60 single-rooted teeth, and TNF-α levels were determined by enzyme-linked immunosorbent assays.
Participant Demographics
60 subjects of different age and sex, divided into three groups based on radiological findings.
Statistical Information
P-Value
<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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