Genetic architecture of prostate cancer in the Ashkenazi Jewish population
Author Information
Author(s): Vijai J, Kirchhoff T, Gallagher D, Hamel N, Guha S, Darvasi A, Lencz T, Foulkes W D, Offit K, Klein R J
Primary Institution: Memorial Sloan-Kettering Cancer Center
Hypothesis
Are prostate cancer risk SNPs associated with prostate cancer in the Ashkenazi Jewish population?
Conclusion
The genetic architecture of prostate cancer in the Ashkenazi Jewish population is similar to that observed in other populations of European ancestry.
Supporting Evidence
- Ten of twenty-three SNPs that passed quality control procedures were associated with prostate cancer risk.
- Nine of these SNPs were originally discovered in studies of individuals of European ancestry.
- The overall genotype call rate was 95%.
Takeaway
This study looked at genetic factors that might increase the risk of prostate cancer in Jewish people from Eastern Europe and found that their genetic risk is similar to other European groups.
Methodology
Genotyping of 29 known prostate cancer risk SNPs in 963 cases and 613 controls of Ashkenazi Jewish ancestry.
Potential Biases
Potential bias due to differences in allele frequencies and haplotype structure between populations.
Limitations
The sample size may be too small to detect more subtle differences in risk between populations.
Participant Demographics
Participants included 963 prostate cancer cases and 613 controls of Ashkenazi Jewish ancestry, with ages ranging from 18 to 98.
Statistical Information
P-Value
p<0.05
Confidence Interval
95% CI=0.81–1.04
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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