Circuit Life Span in Critically Ill Children on Continuous Renal Replacement Treatment
Author Information
Author(s): del Castillo Jimena, López-Herce Jesús, Cidoncha Elena, Urbano Javier, Mencía Santiago, Santiago Maria J, Bellón Jose M
Primary Institution: Hospital General Universitario Gregorio Marañón, Universidad Complutense de Madrid, Madrid, Spain
Hypothesis
What variables are associated with circuit life in critically ill children treated with continuous renal replacement therapy?
Conclusion
Circuit life span in CRRT in children is short but may be increased by the use of hemodiafiltration, higher heparin doses, and filters with a high surface area.
Supporting Evidence
- The median circuit life was 31 hours, with a range from 1 to 293 hours.
- Filters with a surface area of 0.4 m2 or greater were associated with longer life spans.
- Hemodiafiltration resulted in longer circuit life compared to hemofiltration.
- Higher heparin doses (greater than 20 U/kg per hour) were linked to increased filter life.
- Total effluent rates greater than 35 mL/kg per hour were associated with longer filter life.
Takeaway
This study found that the machines used to filter blood in sick children don't last very long, but using certain methods can help them last longer.
Methodology
A prospective observational study analyzing 540 filters in 122 children treated with CRRT from 1996 to 2006.
Potential Biases
Potential bias due to uncontrolled factors affecting vascular access and staff training.
Limitations
The study is descriptive and does not test any intervention, and it may be affected by changes in treatment over time.
Participant Demographics
Median age was 1.4 years, with weights ranging from 2.5 to 85 kg.
Statistical Information
P-Value
0.008, 0.001, 0.01, 0.04
Confidence Interval
95% CI for odds ratios provided in multivariate analysis.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website