How Sepsis Affects Energy Use in Pigs
Author Information
Author(s): Ryan Morse, Gabriella A. M. Ten Have, John J. Thaden, Marielle P. K. J. Engelen, Sarah Rice, Martin Hagve, Nicolaas E. P. Deutz
Primary Institution: Center for Translational Research in Aging and Longevity, Texas A&M University
Hypothesis
In the acute phase of sepsis, altered intestinal amino acid metabolism and breakdown of muscle proteins play a significant role in energy substrate fluxes.
Conclusion
The study found that during acute sepsis, the liver does not increase glucose production adequately, leading to lower blood glucose levels.
Supporting Evidence
- In sepsis, glucose plasma concentration was reduced.
- The splanchnic area showed increased net release of glucose.
- Alanine and lactate release increased in the hindquarter during sepsis.
- Reduced uptake of gluconeogenic amino acids in the portal drained viscera was observed.
Takeaway
When pigs get very sick from sepsis, their bodies struggle to make enough sugar from food, which is important for energy.
Methodology
The study used a porcine model where sepsis was induced in 13 pigs and compared to 9 control pigs, measuring various metabolic fluxes.
Potential Biases
Potential bias due to the small number of animals and the specific model used.
Limitations
The study only examined the acute phase of sepsis and had a relatively small sample size.
Participant Demographics
Female Yorkshire crossbred pigs aged 8–12 weeks and weighing 20–25 kg.
Statistical Information
P-Value
p=0.0028
Confidence Interval
[95% CI]
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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