Intestinal Pseudo-Obstruction After Vincristine Use
Author Information
Author(s): Muacevic Alexander, Adler John R, Monteiro Miguel, Castanheira Beatriz, Meireles Elsa, Príncipe Nuno, Paiva José-Artur
Primary Institution: Centro Hospitalar Universitário de São João
Hypothesis
Vincristine treatment may lead to intestinal pseudo-obstruction in patients undergoing chemotherapy.
Conclusion
Vincristine-induced autonomic neuropathy can cause severe gastrointestinal complications, including intestinal pseudo-obstruction.
Supporting Evidence
- Vincristine is known to cause neurotoxicity and gastrointestinal complications.
- The patient developed symptoms of nausea, abdominal discomfort, and distention after starting vincristine.
- Imaging showed signs of intestinal obstruction without mechanical causes.
- Surgical intervention was necessary due to signs of ischemia.
Takeaway
A 73-year-old man had a serious stomach problem after taking a cancer drug called vincristine, which made his intestines not work properly.
Methodology
Case report detailing the clinical presentation, diagnosis, and treatment of a patient with vincristine-induced intestinal pseudo-obstruction.
Limitations
The findings are based on a single case report, limiting generalizability.
Participant Demographics
73-year-old male with stage III peripheral CD4+ T cell lymphoma.
Digital Object Identifier (DOI)
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