A Retrospective on Nuclear Receptor Regulation of Inflammation: Lessons from GR and PPARs
2011
Nuclear Receptor Regulation of Inflammation
publication
Evidence: moderate
Author Information
Author(s): Li Min-Dian, Yang Xiaoyong
Primary Institution: Yale University
Hypothesis
How do nuclear receptors like GR and PPARs regulate inflammation?
Conclusion
Nuclear receptors play crucial roles in modulating inflammation through various mechanisms, including transrepression of proinflammatory signaling pathways.
Supporting Evidence
- Nuclear receptors can directly inhibit the activities of NF-κB and AP-1.
- PPARs and GR can function synergistically to repress inflammatory gene expression.
- Understanding the mechanisms of nuclear receptor action can lead to novel therapies for chronic inflammation.
Takeaway
Nuclear receptors help control inflammation in the body, which is important for keeping us healthy. They can turn down the activity of genes that cause inflammation.
Methodology
This review summarizes two decades of research on the molecular mechanisms of GR and PPAR transrepression pathways.
Limitations
The review does not provide new experimental data but summarizes existing literature.
Digital Object Identifier (DOI)
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