ID-1 Protein and Cervical Cancer Progression
Author Information
Author(s): Maw M K, Fujimoto J, Tamaya T
Primary Institution: Gifu University School of Medicine
Hypothesis
The study investigates the association between tumor advancement and ID expressions in uterine cervical cancers.
Conclusion
ID-1 expression is linked to poor survival rates in patients with uterine cervical cancer.
Supporting Evidence
- ID-1 histoscores and mRNA levels significantly increased with clinical stage of uterine cervical cancers.
- Patients with high ID-1 expression had a 36-month survival rate of 60%, compared to 83% for those with low ID-1 expression.
- ID-1 expression correlated significantly with microvessel counts in uterine cervical cancers.
Takeaway
This study found that a protein called ID-1 can help doctors understand how advanced a cervical cancer is and how likely a patient is to survive.
Methodology
The study analyzed ID-1, ID-2, and ID-3 mRNA levels using real-time RT-PCR and assessed ID-1 localization through immunohistochemistry in tissue samples from 60 patients.
Participant Demographics
Patients aged 35 to 79 with uterine cervical cancers, including 42 cases of squamous cell carcinoma and 18 cases of adenocarcinoma.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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