Serum Enzyme Activities in Lung Cancer Patients
Author Information
Author(s): Elkiran Emin T, Mar Nefsal, Aygen Bilge, Gursu Ferit, Karaoglu Aziz, Koca Suleyman
Primary Institution: Firat (Euphrates) University School of Medicine
Hypothesis
The study aims to determine serum paraoxonase and arylesterase activities in patients with newly diagnosed lung cancer.
Conclusion
Serum PON1 activity is significantly low in lung cancer patients compared to healthy controls.
Supporting Evidence
- Serum PON1 and ARE activities were lower in lung cancer patients compared to controls.
- The ratio of PON1/HDL was significantly lower in the lung cancer group.
- Positive correlations were found between serum HDL and PON1 levels in both groups.
Takeaway
This study found that patients with lung cancer have lower levels of certain protective enzymes in their blood compared to healthy people.
Methodology
A case-control study comparing serum enzyme activities in 39 lung cancer patients and 39 healthy controls.
Limitations
The study excluded patients with certain conditions that could affect lipid levels, which may limit the generalizability of the findings.
Participant Demographics
39 lung cancer patients (38 males, 1 female) with a mean age of 64.4 years.
Statistical Information
P-Value
0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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