The STEP-HI Study: Testosterone and Exercise Effects on Recovery from Hip Fracture
Author Information
Author(s): Volpi Elena, Kiel Douglas, Paluch Rocco, Dore Peter, Fortinsky Richard, Kuchel George, Orwig Denise, Binder Ellen
Primary Institution: University of Texas Health San Antonio
Hypothesis
Does testosterone replacement therapy combined with resistance exercise improve recovery from hip fracture in older women compared to resistance exercise alone or standard care?
Conclusion
Testosterone replacement therapy combined with exercise improves physical performance in older women recovering from hip fractures.
Supporting Evidence
- Testosterone replacement therapy improved SPPB scores compared to placebo.
- Maximal leg press strength increased in all groups without differences.
- Appendicular lean mass increased in testosterone and placebo groups but decreased in the usual care group.
Takeaway
This study looked at whether giving older women testosterone along with exercise helps them recover better from hip fractures than just exercise or regular care.
Methodology
The study involved intention to treat analyses comparing three groups: testosterone plus exercise, exercise plus placebo, and enhanced usual care.
Participant Demographics
Older women recovering from hip fractures.
Statistical Information
P-Value
p<0.009
Statistical Significance
p<0.009
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website