Helicobacter pylori Genotypes in Jordanian Patients
Author Information
Author(s): Nimri Laila F, Matalka Ismail, Hani Kamal Bani, Ibrahim Marwa
Primary Institution: Jordan University of Science & Technology
Hypothesis
What are the Helicobacter pylori genotypes identified in gastric biopsy specimens from Jordanian patients?
Conclusion
The study found that the predominant H. pylori genotype in Jordanian patients was iceA2, with a low prevalence of the cagA genotype.
Supporting Evidence
- 44% of biopsies were positive for H. pylori by PCR.
- 77.5% of biopsies were positive for H. pylori by histology.
- iceA2 was the predominant genotype found in 73.6% of the samples.
- The vacAs2 allele was more frequently identified than the vacAs1 allele.
Takeaway
This study looked at germs in the stomach of people in Jordan and found that a specific type of germ was very common.
Methodology
Upper endoscopy and gastric biopsies were performed on 250 patients, with PCR and histology used to identify H. pylori genotypes.
Limitations
The study may have false negatives due to the patchy distribution of H. pylori and the effects of prior treatments.
Participant Demographics
The patient population included 58% males and 42% females, with a mean age of 42.03 years.
Statistical Information
P-Value
0.026
Statistical Significance
p<0.02
Digital Object Identifier (DOI)
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