Effects of Du-Huo-Ji-Sheng-Tang on Osteoarthritis in Rabbits
Author Information
Author(s): Chen Chao-Wei, Sun Jian, Li Yu-Mei, Shen Pi-An, Chen Yong-Qiang
Primary Institution: Shanghai Municipal Hospital of Traditional Chinese Medicine
Hypothesis
The study investigates the therapeutic effect of Du-Huo-Ji-Sheng-Tang on cartilage degradation in a rabbit model of osteoarthritis.
Conclusion
Du-Huo-Ji-Sheng-Tang significantly reduces cartilage degradation and apoptosis in osteoarthritis rabbits by inhibiting the expression of VEGF and HIF-1α.
Supporting Evidence
- Histological degeneration was significantly lower in the DHJST group compared to the control group.
- Chondrocyte apoptosis was significantly inhibited in the DHJST group.
- VEGF and HIF-1α expression levels were significantly reduced in the DHJST group.
Takeaway
This study shows that a traditional Chinese medicine can help protect rabbit knees from damage caused by arthritis.
Methodology
Thirty rabbits underwent ACLT to induce osteoarthritis and were treated with Du-Huo-Ji-Sheng-Tang or Osaminethacine for four weeks, followed by histological assessments.
Participant Demographics
New Zealand white rabbits, 48 months old.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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