Placental Lesions in Women with Gestational Hyperglycemia and Diabetes
Author Information
Author(s): Rudge Marilza VC, Lima César P, Damasceno Débora C, Sinzato Yuri K, Napoli Gustavo, Rudge Cibele VC, Gallego Franciane Q, Calderon Iracema MP
Primary Institution: Botucatu Medical School, Univ Estadual Paulista_Unesp, São Paulo State, Brazil
Hypothesis
Histopathological placental lesions are similar in patients with a wide range of glucose tolerance either in preterm or in term.
Conclusion
The distinct placental changes associated with diabetes and mild gestational hyperglycemia depend on the gestational period during which the diabetic insult occurs.
Supporting Evidence
- Placentas from the mild gestational hyperglycemia group showed 17 types of histopathological changes.
- GDM placentas presented only nine types of histopathological changes.
- Overt DM placentas showed 22 types of histopathological changes, with many present in the preterm period.
- The MGH group exhibited a higher incidence of endarteritis compared to the GDM group.
- Maternal glycemic mean increased progressively across the diagnostic groups.
Takeaway
This study looked at the placentas of pregnant women with different levels of blood sugar and found that those with mild hyperglycemia had more specific changes in their placentas.
Methodology
Placental samples were collected from 131 pregnancies and analyzed for histopathological changes using standard staining techniques.
Potential Biases
Potential bias due to the single-pathologist review of histopathological slides.
Limitations
The study was limited to a single hospital and may not be generalizable to all populations.
Participant Demographics
Women with singleton pregnancies, aged between 26.7 to 31.1 years, with varying degrees of glucose tolerance.
Statistical Information
P-Value
<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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