APOE4 Frequencies in Alzheimer's Disease and Dementia with Lewy Bodies
Author Information
Author(s): Kobayashi Seiju, Tateno Masaru, Park Tae Woo, Utsumi Kumiko, Sohma Hitoshi, Ito Yoichi M., Kokai Yasuo, Saito Toshikazu
Primary Institution: Sapporo Medical University School of Medicine
Hypothesis
The study examines the frequencies of the APOE ε4 allele in patients with Alzheimer's disease and dementia with Lewy bodies.
Conclusion
The study found that APOE4 genotypes were similar in Alzheimer's disease and dementia with Lewy bodies, supporting the idea that the ε4 allele is a risk factor for both disorders.
Supporting Evidence
- The rate of APOE4 carrier status was 18.3% in controls and significantly higher in Alzheimer's disease and dementia with Lewy bodies.
- APOE4 genotypes were similar in Alzheimer's disease and dementia with Lewy bodies, suggesting overlapping pathology.
- The study used the latest diagnostic criteria and advanced imaging techniques for accurate diagnosis.
Takeaway
This study looked at a gene that might make people more likely to get Alzheimer's disease or another type of dementia. They found that the gene was common in both groups.
Methodology
The study involved genotyping APOE in 145 patients with probable Alzheimer's disease, 50 patients with probable dementia with Lewy bodies, and a control group of 279 subjects.
Potential Biases
The study may have biases related to the accuracy of clinical diagnoses of dementia.
Limitations
The study had a small sample size and did not confirm diagnoses through neuropathological means.
Participant Demographics
The study included 279 control subjects, 145 patients with probable Alzheimer's disease, and 50 patients with probable dementia with Lewy bodies, with a mean age of 75.6 years for controls.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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