Testing Genetic Links to Kofendred Personality Disorder
Author Information
Author(s): Emma K Larkin, Kevin C Cartier, Courtney Gray-McGuire
Primary Institution: Case Western Reserve University
Hypothesis
Can a regression-based transmission disequilibrium test effectively detect linkage and association for binary traits like Kofendred Personality Disorder?
Conclusion
The method's power to detect genetic links is highly dependent on the density of markers and sample size.
Supporting Evidence
- The maximum power to detect linkage was 93% for chromosome 3 using a 0.3-cM map.
- Type I error was approximately 7%.
- Power increased with larger sample sizes, reaching 100% for chromosome 3 at the finest density.
Takeaway
This study looked at how well a new test can find genetic links to a mental health disorder using different amounts of genetic data.
Methodology
A regression-based transmission disequilibrium test was applied to a simulated dataset to assess power and type I error rates.
Potential Biases
Potential bias due to transmission distortion.
Limitations
The method's effectiveness is limited by the loss of sample size due to uninformative matings.
Participant Demographics
Simulated data from the Aipotu, Danacaa, and Karangar populations.
Statistical Information
P-Value
0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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