SPP1 mRNA and Macrophages in Triple-Negative Breast Cancer
Author Information
Author(s): Chen Yu-Chia, Chen Chia-Ching, Chen Rong-Fu, Chen Hsin-Hung, Chen Po-Ming, Bhatia Madhav
Primary Institution: Kaohsiung Veterans General Hospital
Hypothesis
What is the role of SPP1 mRNA expression in the prognosis of triple-negative breast cancer and its relationship with macrophage infiltration?
Conclusion
SPP1 mRNA expression is associated with poor prognosis in triple-negative breast cancer, particularly linked to M2 macrophage infiltration.
Supporting Evidence
- SPP1 mRNA expression was found to be elevated in TNBC tissues compared to normal tissues.
- High SPP1 expression correlated with poor prognosis in TNBC patients.
- SPP1 expression was significantly linked to M2 macrophage infiltration.
Takeaway
This study found that a specific gene called SPP1 is linked to worse outcomes in a type of breast cancer that is hard to treat, and it seems to be connected to certain immune cells in the body.
Methodology
RNA-seq data from TNBC samples were analyzed alongside normal tissues, and SPP1 expression was examined through immunohistochemistry.
Limitations
The study had a small sample size and incomplete clinical data.
Participant Demographics
Patients diagnosed with breast cancer, with a total of 282 participants included in the study.
Statistical Information
P-Value
0.031
Confidence Interval
95% CI, 1.24 to 1.93
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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