TTF1 Staining and Lung Cancer Survival
Author Information
Author(s): Barlési F, Pinot D, LeGoffic A, Doddoli C, Chetaille B, Torre J-P, Astoul P
Primary Institution: Faculty of Medicine – Assistance Publique Hôpitaux de Marseille
Hypothesis
Does positive thyroid transcription factor 1 (TTF1) staining correlate with survival in patients with adenocarcinoma of the lung?
Conclusion
Positive TTF1 staining strongly and independently correlates with survival of patients with primary adenocarcinoma of the lung.
Supporting Evidence
- Positive TTF1 staining was found in 66% of tumors.
- Patients with positive TTF1 staining had a lower risk of death (HR=0.40).
- The study included 106 patients diagnosed with adenocarcinoma from 2002 to 2004.
Takeaway
If a lung cancer patient has a positive TTF1 test, they are likely to live longer than those who do not.
Methodology
The study analyzed pathological tissue from consecutive adenocarcinoma patients, assessing TTF1 staining and correlating it with survival using Kaplan-Meier and Cox regression analyses.
Potential Biases
Potential bias in patient selection and the retrospective nature of the study.
Limitations
The study only included patients with adenocarcinoma and may not generalize to other types of lung cancer.
Participant Demographics
66% male, 69% with performance status 0-1, 83% with stage III or IV disease.
Statistical Information
P-Value
P<0.0001
Confidence Interval
95% CI 0.25–0.65
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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