Evidence of a large-scale functional organization of mammalian chromosomes: Authors' Reply
2007
Functional Organization of Mammalian Chromosomes
publication
Author Information
Author(s): Shifman Sagiv, Tzenova Bell Jordana, Copley Richard R, Taylor Martin S, Mott Richard, Flint Jonathan, Williams Robert W
Primary Institution: Wellcome Trust Centre for Human Genetics, University of Oxford
Conclusion
The study suggests that the inclusion of advanced intercross lines increases the map length in recombinant inbred lines, enhancing the sensitivity to identify recombination rates.
Supporting Evidence
- Using advanced intercross populations increases the number of recombinants per line.
- Analyzing all recombinant inbred lines together improves sensitivity to identify recombination rates.
Takeaway
The researchers found that using certain mouse genetic lines helps them see how genes are organized and how often they mix together.
Methodology
The study analyzed recombinant inbred lines together to increase the number of recombination events and the density of polymorphic markers.
Digital Object Identifier (DOI)
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