FGF-23: More Than a Regulator of Renal Phosphate Handling?
2010
FGF-23: A Key Regulator of Phosphate Balance
publication
Evidence: high
Author Information
Author(s): Harald Jüppner, Myles Wolf, Isidro B. Salusky
Primary Institution: Massachusetts General Hospital
Hypothesis
Does FGF-23 have roles beyond regulating renal phosphate handling?
Conclusion
FGF-23 is crucial for phosphate homeostasis and may have significant implications in chronic kidney disease.
Supporting Evidence
- FGF-23 is produced by osteocytes and osteoblasts in response to dietary phosphate and vitamin D.
- Elevated FGF-23 levels are associated with chronic kidney disease and predict bone mineralization.
- FGF-23 may have off-target effects contributing to cardiovascular disease in CKD patients.
Takeaway
FGF-23 helps control how much phosphate is in our bodies, especially when our kidneys aren't working well.
Digital Object Identifier (DOI)
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