Tissue Factor in Breast Cancer and Its Prognostic Value
Author Information
Author(s): Ueno T, Toi M, Koike M, Nakamura S, Tominaga T
Primary Institution: Tokyo Metropolitan Komagome Hospital
Hypothesis
Does tissue factor expression in breast cancer tissues correlate with prognosis and plasma concentration?
Conclusion
The study found that plasma tissue factor concentration reflects tissue expression and can predict prognosis and metastasis in breast cancer.
Supporting Evidence
- Plasma tissue factor concentration was higher in breast cancer patients than in normal controls.
- Tissue factor was expressed in both tumor and stromal cells.
- Tumor tissue factor expression was found to be an independent prognostic indicator for overall survival.
Takeaway
This study shows that a substance called tissue factor in breast cancer can help doctors understand how serious the cancer is and if it might spread.
Methodology
The study used ELISA to measure plasma tissue factor and immunohistochemistry to assess tissue expression in breast cancer patients.
Participant Demographics
67 breast cancer patients were included in the plasma study and 213 in the tissue study.
Statistical Information
P-Value
0.0005
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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