Power-free plasma separation for quick blood analysis
Author Information
Author(s): Zeng Lin, Liu Chao, Yang Yi, Hu Shi, Li Ruihan, Tan Xiaotian, Shen Jienan, Zhang Yi, Huang Shaohui, Yang Hui
Primary Institution: Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences
Hypothesis
Can a power-free device based on negative magnetophoresis effectively separate plasma from whole blood for biochemical analysis?
Conclusion
The device can rapidly extract plasma from whole blood without compromising the quality of subsequent analyses.
Supporting Evidence
- The device achieved a plasma recovery rate of 72.7%.
- Separation efficiency for cells larger than 1 μm was 99.9%.
- The device processed human whole blood at a throughput of 3 mL/min.
- Results for COVID-19 IgG detection matched those obtained via centrifugation.
- Plasma separated using this method showed similar characteristics to centrifuged plasma.
Takeaway
This study shows a new way to quickly separate plasma from blood without using electricity, making it easier to test for things like diseases.
Methodology
The study used a power-free device that employs negative magnetophoresis to separate plasma from whole blood samples.
Limitations
The study primarily focused on specific blood volumes and may not address all potential variations in blood composition.
Participant Demographics
Five healthy volunteers provided human whole blood samples.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website