Resveratrol and Colon Cancer: How It Works
Author Information
Author(s): Vanamala Jairam, Radhakrishnan Sridhar, Reddivari Lavanya, Bhat Vadiraja B, Ptitsyn Andrey
Primary Institution: Colorado State University
Hypothesis
Resveratrol suppresses human colon cancer cell proliferation and induces apoptosis via targeting the pentose phosphate and the talin-FAK signaling pathways.
Conclusion
Resveratrol targets specific pathways to suppress cancer cell growth and promote cell death in colon cancer cells.
Supporting Evidence
- Resveratrol suppressed key enzymes in the pentose phosphate pathway, which is important for cancer cell growth.
- The study identified talin and pFAK as critical targets of resveratrol in colon cancer cells.
- Resveratrol's effects were observed even in the presence of IGF-1, a growth factor that promotes cancer cell proliferation.
Takeaway
Resveratrol, a compound found in grapes, can help stop colon cancer cells from growing and make them die.
Methodology
The study used proteomic analysis to examine protein changes in colon cancer cells treated with resveratrol and IGF-1.
Limitations
The study focused on a specific cell line and may not fully represent all colon cancer types.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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