Reduced Bone Density in Young Adults After Childhood Leukemia Treatment
Author Information
Author(s): Brennan B M D, Rahim A, Adams J A, Eden O B, Shalet S M
Primary Institution: Royal Manchester Children's Hospital
Hypothesis
Does treatment for acute lymphoblastic leukaemia in childhood lead to reduced bone mineral density in young adults?
Conclusion
Young adults who were treated for acute lymphoblastic leukaemia in childhood show a significant reduction in bone mineral density.
Supporting Evidence
- There was a significant reduction in vertebral trabecular BMD.
- Lumbar spine integral BMD also showed a significant reduction.
- Forearm cortical BMC was significantly reduced.
- Femoral neck integral BMD showed a lesser but significant reduction.
- No correlation was found between BMD measurements and time since diagnosis.
Takeaway
Kids who had leukemia and got treated might have weaker bones when they grow up.
Methodology
Bone mineral density and markers of bone turnover were assessed in young adults who had received cranial irradiation as part of their leukemia treatment.
Limitations
The study does not account for other potential factors affecting bone density.
Participant Demographics
31 young adults (16 males) who had treatment for acute lymphoblastic leukaemia in childhood.
Statistical Information
P-Value
P < 0.001
Confidence Interval
17.8 (6.8–28.6) years after cranial irradiation
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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