The effect of reduced osmolarity on platinum drug toxicity
1989
Effect of Reduced Osmolarity on Platinum Drug Toxicity
publication
Evidence: moderate
Author Information
Author(s): E. Smith, A.P. Brock
Primary Institution: United Medical and Dental Schools, St Thomas' Hospital
Hypothesis
Reducing the chloride concentration in the drug vehicle might enhance cisplatin toxicity, enabling a lower dose to be given.
Conclusion
Reducing osmolarity may enhance the cytotoxicity of platinum drugs more than chloride concentration does.
Supporting Evidence
- All three platinum agents are more cytotoxic as the osmolarity/chloride concentration is reduced.
- Reducing osmolarity from 300 mosm I1- to 240 mosm I1- caused a three-fold increase in platinum uptake.
- Similar reductions in osmolarity caused a two-fold increase in platinum uptake with CHIP and a six-fold increase with carboplatin.
Takeaway
If you make the liquid that cancer drugs are mixed in less salty, the drugs can work better and kill more cancer cells.
Methodology
CHO cells were treated with platinum drugs in diluted culture medium, and their clonogenicity was assessed after drug exposure.
Limitations
Only minimal changes in osmolarity can be achieved in vivo due to osmoregulatory systems.
Statistical Information
Statistical Significance
p<0.05
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