Striking increase in incidence of prostate cancer in men aged < 60 years without improvement in prognosis
1999

Increase in Prostate Cancer Incidence in Younger Men

publication Evidence: moderate

Author Information

Author(s): Post P N, Stockton D, Davies T W, Coebergh J-W W

Primary Institution: Comprehensive Cancer Centre South

Hypothesis

The considerable increase in incidence of prostate cancer in men under 60 is not solely due to increased detection.

Conclusion

The study found an increase in the incidence of fatal prostate cancer among younger men even before the introduction of PSA testing.

Supporting Evidence

  • Age-standardized incidence of prostate cancer increased significantly in both regions studied.
  • Five-year relative survival rates did not improve and even declined in some cases.
  • Mortality due to prostate cancer increased significantly among men aged 45-64 years.

Takeaway

More young men are being diagnosed with prostate cancer, but their chances of survival haven't improved.

Methodology

The study analyzed incidence, mortality, and relative survival among middle-aged patients diagnosed in south-east Netherlands and East Anglia (UK) between 1971 and 1994.

Participant Demographics

Middle-aged men diagnosed with prostate cancer in south-east Netherlands and East Anglia.

Statistical Information

Confidence Interval

95% CI 47–83; 95% CI 34–62

Digital Object Identifier (DOI)

10.1038/sj.bjc.6690004

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