Modulation of Cytokine Production by Carnitine
Author Information
Author(s): Nicola M. Kouttab, Claudio De Simone
Primary Institution: Roger Williams Medical Center and Brown University; University of L'Aquila
Hypothesis
Can carnitine congeners modulate cytokine production by human peripheral blood mononuclear cells?
Conclusion
Carnitine may modulate immune functions through the production of selected cytokines, with a more pronounced effect in younger donors.
Supporting Evidence
- Significant production of TNF was observed in four of five young donors but only one of five old donors.
- IL-1 and IL-6 production was also significantly induced at higher doses of L-carnitine.
- Acetyl L-carnitine induced significant concentrations of TNF in young donors.
Takeaway
Carnitine can help the body produce important substances that fight off sickness, especially in younger people.
Methodology
Peripheral blood mononuclear cells were collected and incubated with acetyl L-carnitine and L-carnitine at various concentrations, and cytokine production was measured using ELISA.
Limitations
The small number of donors limits the ability to draw definitive conclusions.
Participant Demographics
Young donors (30 years or younger) and old donors (70 years or older).
Statistical Information
Statistical Significance
p<0.05
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