SIRI as a Predictor of Short-Term Outcomes in Heart Failure
Author Information
Author(s): Xie Lin, Wang Qun, Lu Hengcheng, Kuang Maobin, He Shiming, Xie Guobo, Sheng Guotai, Zhang Shuhua, Wang Wei, Zou Yang
Primary Institution: Jiangxi Cardiovascular Research Institute, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College
Hypothesis
This study aims to evaluate the impact and predictive value of the systemic inflammation response index (SIRI) on short-term adverse outcomes in acute decompensated heart failure (ADHF) patients.
Conclusion
The study demonstrates a significant linear positive correlation between SIRI and 30-day mortality in ADHF patients, highlighting its substantial predictive value.
Supporting Evidence
- During the 30-day follow-up, 53 deaths were recorded among the 1,448 ADHF patients.
- Mortality rates across SIRI tertiles were 0.62%, 2.07%, and 8.28%, respectively.
- Compared to ADHF patients with low SIRI, those with high SIRI had a 685% increased risk of 30-day mortality.
- SIRI significantly improved the predictive value for 30-day mortality in ADHF patients compared to other inflammatory markers.
Takeaway
This study found that a blood test called SIRI can help doctors predict how likely it is for heart failure patients to get worse or die within 30 days.
Methodology
This retrospective cohort study included 1,448 ADHF patients and used Cox regression analysis and receiver operating characteristic curves to assess the predictive value of SIRI for 30-day mortality.
Potential Biases
As an observational study, residual confounding cannot be entirely eliminated.
Limitations
The study's findings may not be generalizable beyond the southern Chinese population, and it cannot assess the impact of anti-inflammatory treatments on outcomes.
Participant Demographics
The study included 1,448 ADHF patients, with 832 males and 616 females, and an average age of 68 years.
Statistical Information
P-Value
0.113
Confidence Interval
1.02-1.44
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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