Differential Expression of Cytokeratins in Ovarian and Colorectal Adenocarcinoma
Author Information
Author(s): Rekhi Bharat, George Sophia, Madur Bhulaxmi, Chinoy RF, Dikshit Rajesh, Maheshwari Amita
Primary Institution: Tata Memorial Hospital, Mumbai, India
Hypothesis
Can differential expression of cytokeratins 7 and 20 help distinguish between ovarian and colorectal adenocarcinomas?
Conclusion
Differential expression of cytokeratins 7 and 20 is useful in resolving diagnostic dilemmas between ovarian and colorectal adenocarcinomas.
Supporting Evidence
- 45% of cases were colorectal adenocarcinomas metastatic to the ovary.
- 55% of cases were ovarian adenocarcinomas metastatic to the colorectum.
- CK20 positivity and CK7 negativity are associated with colorectal adenocarcinoma.
Takeaway
This study looked at 20 cases to see how certain markers can help doctors tell if a cancer in the ovary came from the colon or if it started in the ovary.
Methodology
Analysis of 20 cases of ovarian involvement by metastatic colorectal adenocarcinomas and vice-versa, including immunohistochemistry for cytokeratins.
Limitations
Limited details on some cases due to referral nature of the study.
Participant Demographics
Median age of colorectal adenocarcinoma cases was 55 years; median age of ovarian adenocarcinoma cases was 49 years.
Digital Object Identifier (DOI)
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