Effects of Anti-TNF-α Therapy on Psoriatic Arthritis
Author Information
Author(s): Cordiali-Fei Paola, Trento Elisabetta, D'Agosto Giovanna, Bordignon Valentina, Mussi Anna, Ardigò Marco, Mastroianni Antonio, Vento Antonella, Solivetti Francesco, Berardesca Enzo, Ensoli Fabrizio
Primary Institution: San Gallicano Dermatology Institute, Rome, Italy
Hypothesis
The study investigates the role of MMP-9 in psoriasis and its association with TNF-α production.
Conclusion
The study found that anti-TNF-α therapy significantly decreases MMP-9 levels in patients with psoriatic arthritis, suggesting its role in the inflammatory process.
Supporting Evidence
- All but one patient showed significant improvement in PASI scores after therapy.
- MMP-9 levels significantly decreased after treatment.
- Significant correlations were found between PASI measurements and levels of TNF-α, MMP-9, and E-selectin.
Takeaway
This study shows that a medicine called Infliximab helps people with skin problems by lowering a harmful substance in their skin.
Methodology
The study involved 11 psoriatic patients receiving Infliximab therapy, with assessments of serum and skin biopsy samples before and after treatment.
Potential Biases
Potential biases may arise from the small sample size and the specific treatment protocol used.
Limitations
The study had a small sample size and was limited to a specific patient population.
Participant Demographics
9 males and 2 females, aged 35–60 years.
Statistical Information
P-Value
P = 0.017
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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