Notes from the Field: Geo-Temporal Trends in Fentanyl Administration Routes Among Adults Reporting Use of Illegally Manufactured Fentanyl When Assessed for Substance-Use Treatment — 14 U.S. States, 2017–2023
2024

Trends in Fentanyl Use and Administration Routes

Sample size: 16636 publication 10 minutes Evidence: moderate

Author Information

Author(s): Chen Yijie, Jiang Xinyi, Gladden R. Matthew, Nataraj Nisha, Guy Gery P. Jr., Dowell Deborah

Primary Institution: Centers for Disease Control and Prevention

Hypothesis

What are the trends in administration routes of illegally manufactured fentanyl among adults seeking substance-use treatment?

Conclusion

The study found a significant decline in the injection of illegally manufactured fentanyl and an increase in smoking and snorting it across various U.S. regions from 2017 to 2023.

Supporting Evidence

  • From 2020 to 2022, smoking of illegally manufactured fentanyl increased by 78.9%.
  • Injection of illegally manufactured fentanyl decreased by 41.6% during the same period.
  • Significant regional differences were observed in the trends of fentanyl administration routes.

Takeaway

More people are smoking or snorting fentanyl instead of injecting it, which might be safer but still poses risks.

Methodology

The study analyzed treatment assessments from adults aged ≥18 years who reported using illegally manufactured fentanyl in the past 30 days across 14 states.

Potential Biases

Potential bias due to self-reported data and the convenience sampling method.

Limitations

The study is based on a convenience sample and may not represent all users of illegally manufactured fentanyl.

Participant Demographics

Adults aged 18 and older assessed for substance-use treatment.

Statistical Information

P-Value

<0.001

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.15585/mmwr.mm7350a4

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