Arginine Methylation and Its Role in Chronic Lung Diseases
Author Information
Author(s): Zakrzewicz Dariusz, Eickelberg Oliver
Primary Institution: University of Giessen Lung Center
Hypothesis
Dysregulated arginine methylation contributes to the pathogenesis of chronic lung diseases.
Conclusion
Dysregulated arginine methylation is implicated in the development of chronic lung diseases, suggesting potential therapeutic targets.
Supporting Evidence
- ADMA and MMA are endogenous inhibitors of nitric oxide synthases.
- Elevated ADMA concentrations have been detected in the plasma of patients with pulmonary arterial hypertension.
- Disrupted methylarginine metabolism impairs vascular homeostasis in pulmonary arterial hypertension.
Takeaway
This study talks about how a process called arginine methylation can go wrong and lead to lung diseases. By fixing this process, we might be able to help people with these diseases.
Methodology
The review discusses recent findings and mechanisms related to arginine methylation in chronic lung diseases.
Limitations
The review does not provide new experimental data but summarizes existing literature.
Digital Object Identifier (DOI)
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