Fascin, an actin-bundling protein associated with cell motility, is upregulated in hormone receptor negative breastancer
2000
Fascin and Hormone Receptor Negative Breast Cancer
Sample size: 58
publication
Evidence: moderate
Author Information
Author(s): Grothey A, Hashizume R, Sahin A A, McCrea P D
Primary Institution: University of Texas, MD Anderson Cancer Center
Hypothesis
The study investigates the relationship between fascin expression and hormone receptor status in breast cancer.
Conclusion
Fascin is upregulated in hormone receptor-negative breast cancers, which may lead to more aggressive tumor behavior.
Supporting Evidence
- Loss of hormone receptor status in breast carcinomas is associated with increased tumor cell motility and invasiveness.
- Oestrogen and progesterone receptor levels were inversely correlated with the expression of fascin.
- Fascin was preferentially expressed in non-diploid tumors.
Takeaway
Fascin is a protein that helps cancer cells move, and when breast cancer cells don't have hormone receptors, they have more of this protein, making them more aggressive.
Methodology
Immunohistological study of primary breast cancers.
Statistical Information
P-Value
P< 0.0001 and P = 0.0019
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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