Letrozole vs Clomiphene for Infertility Treatment
Author Information
Author(s): Fouda Usama M, Sayed Ahmed M
Primary Institution: Cairo University
Hypothesis
The study aims to compare the efficacy of an extended letrozole regimen with clomiphene citrate in women with unexplained infertility undergoing superovulation and intrauterine insemination.
Conclusion
The extended letrozole regimen had superior efficacy compared to clomiphene citrate in patients with unexplained infertility undergoing superovulation and IUI.
Supporting Evidence
- The pregnancy rate per cycle was 18.96% for the letrozole group compared to 11.43% for the clomiphene group.
- The cumulative pregnancy rate was 37.73% for the letrozole group versus 22.86% for the clomiphene group.
- Serum estradiol levels were significantly higher in the clomiphene group.
- Endometrial thickness was significantly greater in the letrozole group.
Takeaway
This study found that using letrozole instead of clomiphene can help women with unexplained infertility get pregnant more effectively.
Methodology
A randomized controlled trial with 214 women divided into two groups receiving either letrozole or clomiphene citrate, followed by intrauterine insemination.
Potential Biases
Potential bias due to non-blinding of patients and caregivers to treatment protocols.
Limitations
The study was limited to women with unexplained infertility and may not be generalizable to other infertility causes.
Participant Demographics
Women aged 18-37 with unexplained infertility, normal hormonal profiles, and patent fallopian tubes.
Statistical Information
P-Value
< 0.001
Confidence Interval
1.81 (1.05, 3.13)
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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